Neuroventralio tinktūros ir skystojo raminamojo ekstrakto bei tablečių vaikams technologijos ir jų vertinimas

Show simple item record Kalvėnienė, Zenona 2017-08-21T08:05:08Z 2017-08-21T08:05:08Z 2005
dc.description.abstract 1. GENERAL CHARACTERICTICS OF THE WORK First drugs were of herbal origin. Today, preparations of this kind are highly appreciated. Social and economic changes have been influencing public health. The rhythm of life and nervous strain have negative effects on the human body. Many ailments are caused by emotional variations. Illnesses of the nervous system and related disorders of the digestive system raise an important concern nowadays. The potential of phytopreparations in the treatment of such ailments is capable of completing the gaps of their treatment. Phytopreparations can be used for treatment for an extensive period of time. Critics of phytotherapy can argue that existence of modern synthetic medicine supersedes phytopreparations. It must be noted, though, that this medicine is effective and easily digested. It does not compete with, but only complements pharmacotherapy. Phytopreparations are often used in the treatment of chronic disorders of the digestive system such as higher sensitivity, atony, ailments of bile bladder and duct. Functional disorders of intestine cause diarrhea, spasmodic pains, stomach rumble, and loose bowels. In case of functional stomach and intestine disorders, treatment with sedative and peristalsis regulating medicine is applied in addition to a rational daily routine and diet. Digestive disorders are well eliminated with the help of herbal drugs. At present, medicinal herbs and preparations from herbal materials have been receiving a lot of attention. In the law prepared by the EU Parlament, herbs and herbal medicines have been recognized as equals to chemical drugs. This is determined by increasing popularity of phytopreparations. In Germany and France, herbal drugs account for 50 percent of the market. They are highly demanded by the citizens of Great Britain, Spain and Italy. Recently registered herbal and animal drugs in Lithuania account for 7 percent of all registered medicines. Modern phytopreparations are researched using similar methods of analysis to those applied to chemical drugs, and their results are estimated according to analogous criteria. Due to their rare side effects, most herbal preparations have been often considered superior to the synthetic ones. The complex of biologically active substances, such as saponines, tanines, alkaloids, flavonoids, vitamins, glycosides and microelements, which is present in medicinal herbs has a beneficial effect on the human body. Their amounts found in herbs are relatively small; yet, they do enhance recovery of the body if properly combined. It has been found that during their interaction with the systems of self-control and stability, phytopreparations inhibit or stimulate them, and thus, affect the symptoms of a disease. Applying certain technologies, such as extraction, distillation, pressing, fractioning, purification, concentration and fermentation, produces medicinal herbal preparations. Dosage forms of herbal preparations include pulverized or crushed ex herbal raw materials, tinctures, extracts, ethereal and fat oils, expressed juice and processed extractions. In Lithuania, many different dosage forms of herbal preparations are registered, including teas, tablets, capsules, oils, balms, gels, ointments, suppositories, extractions, tinctures, syrups, juices, etc. The biggest part of these preparations is constituted by single-component teas. Most herbal teas are intended for treatment of some particular digestion disorders, such as enhancing the release of gastric juices, stimulating the appetite, eliminating spasms of the intestines, stimulating bile release, reducing stomach distention, stifling of nausea and treatment of gastritis, hepatitis, and gastric and duadenum ulcer. A very important sphere of treatment is ailments of nervous nature. Herbal teas are used when having depression, anxiety or higher nervous strain. A very important group of medicinal herbal preparations is extracts. They are prepared both from a single herbal raw material and from several herbs, but the major part, i.e. 72 per cent, are multi-component preparations. Composition of such preparations includes 5, 6 or even 8 herbal raw materials. There therapeutically actions complement each other. In our country, the major manufacturers of herbal extracts are „Sanitas“, „Bakteriniai preparatai“, „Korio laboratorija“. In Lithuania, there are over 20 registered brands of drugs from medicinal herbal raw materials; however, there are no herbal preparations for children. Foreign manufacturers offer Carminatyvum Babynos drops and Melisal syrup, the highly demanded preparations for children. Analysis of the registered herbal preparations in the Republic of Lithuania has confirmed that launching composite preparations for eliminating gastric disorders for childern and adults in the pharmaceutical market is both valuable and relevant. When selecting herbal materials for composition of nervine and complex digesting disorders eliminating tincture, they were combined so that their pharmacologically active substances would target some particular symptoms and would complement each other’s action. St John’s wort herb and lavender flowers are distinguished by their nerve calming and depression syndrome eliminating effect. Other components of the tincture are intended for elimination of functional digestive disorders. Therefore, several herbal raw materials were chosen: ginger rhizome, which is distinguished by its antiemetic, spasmolytic and stimulating release of gastric juices, saliva and bile effect; rosemary leaves, which are distinguished by their anti-spasmodic effect on bile ducts and small intestine; cinnamon bark, as a cure enhancing intestine peristalsis and reducing flatulence. For preparation of a liquid sedative extract for children, sufficiently explored and traditionally used medicinal herbal raw materials with no toxic effects were chosen. The pharmacological action of each component has been sufficiently researched and verified by the experience of their application. Ingredient compatibility and their possible synergistic action were also taken into account. Lemon balm leaves is distinguished by its spasmolytic and sedative action; therefore, it is frequently used for the treatment of sleep disorders and insomnia, which are caused by functional digestive disorders. Camomile flowers have been widely used for their sedative and spasmolytic effects. In many European countries, camomile flowers are used for the treatment of insomnia and as a mild sedative drug. Flavonoids, organic acids and ascorbic acid, which are present in hawthorn fruit, reduce irritation of nervous system, normalize the heart rhythm, enhance blood circulation of the heart and the brain. Hawthorn preparations are often used as a sedative drug together with other herbal preparations for reduction of anxiety. Lime blossoms are distinguished by their spasmolytic, mild seductive and perspiration stimulating effect. 1.1. The aim and objectives of the research The aim of the research is to develop technologies of the following stable extractive preparations-a tincture, a liquid and dry sedative extract and sedative tablets for children technologies and to evaluate them. The objectives of the research: 1. To prepare a complex tincture from St John’s wort, cinnamon bark, rosemary leaves, lavender flowers and ginger rhizome: - to develop a formulation for the tincture; - to explore the properties (fineness of raw material, duration of swelling and determination of absorption coefficient) of the mixture of St John’s wort, cinnamon bark, rosemary leaves, lavender flowers and ginger rhizome; - to determine production conditions and to apply methods of analysis; - to assess the influence of technological factors on the quality of the tincture by applying the multi-factor dispersive analysis; - to evaluate the stability; - to prepare standard technical documentation for Neuroventralis 2 tincture; 2. To prepare a fluid and dry sedative extract for children from camomile flowers and lime blossoms, hawthorn fruit and lemon balm leaves: - to develop a formulation of the liquid sedative extract; - to assess the influence of properties (fineness of raw material, duration of swelling, and absorption coefficient) of the mixture of camomile flowers, lime blossoms and lemon balm leaves on the quality of extraction; - to assess the influence of technological factors on the quality of extraction by applying dispersive analysis; - to apply production conditions and methods of analysis for the liquid extraction; - to determine stability of the preparation; - to prepare a dry sedative extract; to suit a mode of the dryer; - to assess the quality of the dry extract; to develop suitable methods of analysis. 3. To prepare tablets containing a sedative dry extract: - to develop a formulation for the tablets; - to suit production methods; - to suit methods of analysis; - to evaluate stability of the tablets. 2. NOVELTY OF THE WORK AND ITS PRACTICAL SIGNIFICANCE A tincture of original composition, Neuroventralis 2, has been produced. It is intended for elimination of disorders of gastric and intestine functioning related to depressive condition. The influence of properties of the mixture of St John’s wort herb, cinnamon bark, rosemary leaves, lavender flowers and ginger rhizome on the production of the tincture has been assessed; such technological peculiarities of the preparation as extrahent and conditions of extraction method have been analysed. The composition of the tincture has been patented at the National Patent Office. The standard technical documentation, i.e. pharmacopoeia article Tincture Neuroventralis 2. Ph. Art. 542:2001, has been prepared and approved. The preparation has been included into the National Drugs Register (reg. No. 02/8041/10). During the development of the liquid sedative extract for children, properties of the mixture of medicinal herbal raw materials of camomile flowers, lime
dc.language.iso lit
dc.subject Fitopreparatai
dc.subject Augaliniai preparatai vaikams
dc.subject Preparations for children.
dc.subject Ekstrahavimas
dc.subject Tabletės
dc.subject Phytopreparations
dc.subject Extraction
dc.title Neuroventralio tinktūros ir skystojo raminamojo ekstrakto bei tablečių vaikams technologijos ir jų vertinimas
dc.title.alternative Neuroventralis tincture, liquid sedative extract and tablets for children technologies and their evaluation
dc.type Daktaro disertacija

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