LITHUANIAN UNIVERSITY OF HEALTH SCIENCES LUHS LIBRARY REPOSITORY

Varlės vidurinių smegenų stogo (tectum) neuronų aktyvumo, sujaudinus vieną tinklainės ganglinę ląstelę, tyrimas

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dc.contributor.author Batulevičienė, Vaida
dc.date.accessioned 2017-08-21T08:07:24Z
dc.date.available 2017-08-21T08:07:24Z
dc.date.issued 2006
dc.identifier.uri http://repository.lsmuni.lt/handle/1/60063
dc.description.abstract It is considered that coincident inputs from multiple presynaptic axons are required to achieve both the suprathreshold level of excitation for the central neurons and the activation of NMDA receptors. The aim of the present study was to determine, whether a discharge of single retinal ganglion cell, which axon terminates in the tectum layer F, can evoke a suprathreshold excitation of frog tectum neurons and activate the NMDA receptors. Extracellular recordings of the neuronal activity elicited by the electrical stimulation of single optic fiber were made in frog tectum. We conclude, that: (1) a train of action potentials of single optic fiber, which terminates in the frog tectum layer F, surely elicits a suprathreshold excitation of tectal neurons at physiological conditions. The suprathreshold level is achieved due to the frequency facilitation of the fast non-NMDA retinotectal synaptic potentials. (2) The train of action potentials of higher frequency activates the NMDA receptors of the tectal neurons at physiological conditions. The activation of NMDA receptors is achieved due to the temporal summation and frequency facilitation of the fast synaptic potentials. (3) Two different kinds of optic fibers (likely darkness and moving edge detectors) exhibit different efficiency to achieve both the suprathreshold excitation of the tectal neurons and the activation of NMDA receptors. Findings of the present study improve the understanding of how the local neural network operates.
dc.language.iso lit
dc.subject NMDA receptors
dc.subject Biology
dc.subject Suprathreshold excitation
dc.subject Viršslenkstinis sujaudinimas
dc.subject Retinotektalinis perdavimas
dc.subject NMDA receptoriai
dc.subject Retinotectal transmission
dc.subject Biologija
dc.title Varlės vidurinių smegenų stogo (tectum) neuronų aktyvumo, sujaudinus vieną tinklainės ganglinę ląstelę, tyrimas
dc.title.alternative Research of frog tectal neurons activity elicited by discharge of single retina ganglion cell
dc.type Daktaro disertacija


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